Author: Mushroom References

Coriolus versicolor Mushroom Polysaccharides Exert Immunoregulatory Effects on Mouse B Cells Via Membrane Ig and TLR-4 to Activate the MAPK and NF-κB Signaling Pathways

“Together, we demonstrate that CVP can bind and induce B cell activation using membrane Ig and TLR-4 as potential immune receptors. CVP activates mouse B cells through the MAPK and NF-κB signaling pathways.” ABSTRACT: This study aimed to characterize the immunopotentiating effects and immune receptors for Coriolus versicolor mushroom polysaccharides (CVP), a Chinese medicinal fungus …

Read More Coriolus versicolor Mushroom Polysaccharides Exert Immunoregulatory Effects on Mouse B Cells Via Membrane Ig and TLR-4 to Activate the MAPK and NF-κB Signaling Pathways

Anti-diabetic effects of Ganoderma lucidum

“G. lucidum polysaccharides have been reported to have hypoglycemic activity by increasing plasma insulin levels and decreasing plasma sugar levels in mice. Protein tyrosine phosphatase 1B is a promising therapeutic target in diabetes, and G. lucidum proteoglycan can inhibit this enzyme in vitro. Moreover, G. lucidum triterpenoids were shown to have inhibitory activity on aldose …

Read More Anti-diabetic effects of Ganoderma lucidum

Antiviral activities of Boletus edulis, Pleurotus ostreatus and Lentinus edodes extracts and polysaccharide fractions against herpes simplex virus type 1

“Pre-treatment of Vero cells with 75 mg·ml-1 water extracts before virus addition, inhibited 60% of the virus infection and its addition during the virus adsorption period inhibited it up to 80%. Moreover, the mushrooms water extracts were able to significantly inhibit the in vitro virus replication, showing the concentration of a substance required to reduce …

Read More Antiviral activities of Boletus edulis, Pleurotus ostreatus and Lentinus edodes extracts and polysaccharide fractions against herpes simplex virus type 1

Anti inflammatory activity on mice of extract of Ganoderma lucidum grown on rice via modulation of MAPK and nf-kb pathways

“These findings suggest that GLBR is protective against colitis via inhibition of MAPK phosphorylation and NF-kB activation.” ABSTRACT: Ganoderma lucidum is a popular medicinal mushroom with anti-inflammatory potential. In the present study, the aim was to determine the anti-inflammatory effect and mode of action of G. lucidum grown on germinated brown rice (GLBR) in a …

Read More Anti inflammatory activity on mice of extract of Ganoderma lucidum grown on rice via modulation of MAPK and nf-kb pathways

Maitake mushroom extract in myelodysplastic syndromes (MDS): A phase II study

“Enhanced in vitro neutrophil and monocyte function following treatment demonstrate that Maitake has beneficial immunomodulatory potential in MDS.” ABSTRACT: BACKGROUND: Myelodysplastic syndromes (MDS) are characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral cytopenia, risk of infection, and progression to acute myelogenous leukemia. Maitake mushroom beta-glucan, a dietary supplement, stimulates hematopoietic progenitor cell …

Read More Maitake mushroom extract in myelodysplastic syndromes (MDS): A phase II study

Protective effect of Hericium erinaceus on alcohol induced hepatotoxicity in mice

“HEM administration markedly (P < 0.05) decreased serum ALT, AST, and MDA levels.” ABSTRACT: We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. HEM (200 mg/kg BW) was gavage …

Read More Protective effect of Hericium erinaceus on alcohol induced hepatotoxicity in mice

Protective effect of ethanol extracts of Hericium erinaceus on alloxan-induced diabetic neuropathic pain in rats

“After 6 weeks of treatments, treatment with HEE 40 mg/kg in diabetic animals showed significant increase in pain threshold and paw withdrawal threshold and significant decrease in serum glucose and urine glucose.” ABSTRACT: We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats. Alloxan induced diabetic rats were …

Read More Protective effect of ethanol extracts of Hericium erinaceus on alloxan-induced diabetic neuropathic pain in rats

Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of inos/p38 MAPK and nitrotyrosine

“Levels of nitrotyrosine-containing proteins, phosphorylation of p38 MAPK and CCAAT enhancer-binding protein (C/EBP) and homologous protein (CHOP) expression were attenuated by erinacine A. Moreover, the modulation of ischemia injury factors present in the SAM model by erinacine A seemed to result in the suppression of reactive nitrogen species and the downregulation of inducible NO synthase …

Read More Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of inos/p38 MAPK and nitrotyrosine

Evaluation of anticonvulsant, antidepressant-, and anxiolytic-like effects of an aqueous extract from cultured mycelia of the lingzhi or reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) in mice

“The studied extract (100-400 mg/kg) significantly increased the threshold for psychomotor seizures in the 6-Hz seizure test. In the forced swim test, G. lucidum (100-400 mg/kg) significantly reduced the duration of immobility.” ABSTRACT: Ganoderma lucidum is a well-known medicinal mushroom with a long history of use. This study was designed to assess the anticonvulsant potential …

Read More Evaluation of anticonvulsant, antidepressant-, and anxiolytic-like effects of an aqueous extract from cultured mycelia of the lingzhi or reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) in mice

Effects of comb tooth cap medicinal mushroom, Hericium ramosum (higher basidiomycetes) mycelia on DPPH radical scavenging activity and nerve growth factor synthesis

“Oral administration of H. ramosum mycelia significantly increased concentrations of NGF in the hippocampus of intact mice.” ABSTRACT: The goal of this study was to evaluate the antioxidant effects of and nerve growth factor (NGF) synthesis caused by Hericium ramosum mycelia. Wild mushroom fruiting bodies were collected from nature to isolate their mycelia. Pieces of …

Read More Effects of comb tooth cap medicinal mushroom, Hericium ramosum (higher basidiomycetes) mycelia on DPPH radical scavenging activity and nerve growth factor synthesis

Improving effects of the mushroom yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial

“At weeks 8, 12 and 16 of the trial, the Yamabushitake group showed significantly increased scores on the cognitive function scale compared with the placebo group. The Yamabushitake group’s scores increased with the duration of intake, but at week 4 after the termination of the 16 weeks intake, the scores decreased significantly.” ABSTRACT: A double-blind, …

Read More Improving effects of the mushroom yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial

Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

“Our results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus.” ABSTRACT: Hericium erinaceus, a well known edible mushroom, has numerous biological activities. Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which …

Read More Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

Antiviral activity of Inonotus hispidus

ABSTRACT: The antiviral activity of two phenolic compounds, hispolon and hispidin, isolated from the fruit bodies of the basidiomycete Inonotus hispidus as well as of some extracts prepared from fruit bodies and mycelial cultures of this fungus was investigated in allantois on the shell-test system. Ethanolic extracts, hispidin and hispolon showed considerable antiviral activity against …

Read More Antiviral activity of Inonotus hispidus

Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures

ABSTRACT: Fractions of Inonotus obliquus fungus water extract exhibited a virucidal effect towards hepatitis C virus: it 100-fold reduced its infective properties within 10 min. The antiviral effects of fungus extracts manifested after preventive (24 h before infection) and therapeutic use (during infection of porcine embryo kidney cells). Moreover, the data indicate that the birch …

Read More Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures

Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12

“The mice experiments demonstrated that RPS could reduce the levels of blood and liver lipid, and improve the glutamate pyruvate transaminase and antioxtidant activity. The histopathological observations of mice livers indicated that RPS could attenuate liver cell injury.” ABSTRACT: Cordyceps militaris has been artificially cultivated in China, and the great amounts 36of produced medium residue …

Read More Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12

Polyoxygenated ergostane-type sterols from the liquid culture of Ganoderma applanatum.

ABSTRACT: A new polyoxygenated ergostane-type sterol, 3β,5α,6β,8β,14α-pentahydroxy-(22E,24R)-ergost-22-en-7-one (1), has been isolated from the liquid culture of the basidiomycete Ganoderma applanatum together with four known sterols, 3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (2), ergosterol peroxide (3), 6-dehydrocerevisterol (4) and cerevisterol (5). Two of these sterols (2, 4) are reported to have been isolated from this species for the first time. The …

Read More Polyoxygenated ergostane-type sterols from the liquid culture of Ganoderma applanatum.

Evaluation of anticonvulsant, antidepressant-, and anxiolytic-like effects of an aqueous extract from cultured mycelia of the lingzhi or reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) in mice

“In the forced swim test, G. lucidum (100-400 mg/kg) significantly reduced the duration of immobility.” ABSTRACT: Ganoderma lucidum is a well-known medicinal mushroom with a long history of use. This study was designed to assess the anticonvulsant potential of an aqueous extract from cultured G. lucidum mycelium in 3 acute seizure models: timed intravenous pentylenetetrazole …

Read More Evaluation of anticonvulsant, antidepressant-, and anxiolytic-like effects of an aqueous extract from cultured mycelia of the lingzhi or reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) in mice

Modulation of T cell response by Phellinus linteus

“P. linteus fermented broths produced additive effects on the regulation of the Th1/Th2 balance and show promise for the development of immunomodulatory therapeutics.” ABSTRACT: Phellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective …

Read More Modulation of T cell response by Phellinus linteus

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

“Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels-but also maintains intestinal barrier integrity and reduces metabolic endotoxemia. The anti-obesity and microbiota-modulating effects are transmissible via horizontal faeces transfer from WEGL-treated mice to HFD-fed mice.” ABSTRACT: Obesity is associated with low-grade chronic inflammation …

Read More Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties

“These results indicate that different extracts of investigated mushroom have considerable cytotoxic, antioxidant and antibacterial properties and may be utilized as a promising source of therapeutics.” ABSTRACT: BACKGROUND: Mushrooms have been valued for their nutritive content and as traditional medicines; several important medicinal properties of mushrooms have been recognized worldwide. OBJECTIVE: The purpose of this …

Read More Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties

Regulation of primary metabolic pathways in oyster mushroom mycelia induced by blue light stimulation: Accumulation of shikimic acid

“Shikimic acid is a key intermediate in the aromatic amino acid pathway as well as an important starting material for the synthesis of Tamiflu, a potent and selective inhibitor of the neuraminidase enzyme of influenza viruses A and B. Here we report that in oyster mushroom (Pleurotus ostreatus) mycelia cultivated in the dark, stimulation with …

Read More Regulation of primary metabolic pathways in oyster mushroom mycelia induced by blue light stimulation: Accumulation of shikimic acid

Evaluation of the Antioxidant Activities and Tyrosinase Inhibitory Property from Mycelium Culture Extracts

“Overall, our study suggested potential candidates for [ethanol extract of culture media including mycelium] that exhibited powerful antioxidant and tyrosinase inhibitory properties and might be used as natural antioxidant tyrosinase inhibitor.” ABSTRACT: Since mushrooms have many bioactive components, they have been used as components in folk medicine. Because mycelium has an advantage when it comes …

Read More Evaluation of the Antioxidant Activities and Tyrosinase Inhibitory Property from Mycelium Culture Extracts

Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

“Atractylenolide I has not been reported in mushrooms or rice as of yet. The isolated compound dose-dependently inhibited the growth of HT-29 human colon cancer cells.” ABSTRACT: Objective: To isolate and identify the anticancer compound against proliferation cancer cells from ethyl acetate (EtOAc) extract of Phellinus linteus grown on germinated brown rice (PB). Methods: EtOAc …

Read More Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

Chemical, toxicological, anti-inflammatory and antimicrobial evaluation of Ganoderma lucidum extracts

“When a mixture is made of water extract with alcohol, there is a higher concentration of beta-glucan with protein and phenol.” ABSTRACT: Ganoderma lucidum (Fr.) Krast, a basidiomycete belonging to the Ganodermataceae family is one of the most famous traditional Chinese medicinal herbs, used as a healthy food and in medicine. In Brazil, some people …

Read More Chemical, toxicological, anti-inflammatory and antimicrobial evaluation of Ganoderma lucidum extracts

The contribution of phenolic acids to the anti-inflammatory activity of mushrooms

“The extracts of Pleurotus ostreatus, Macrolepiota procera, Boletus impolitus and Agaricus bisporus revealed the strongest anti-inflammatory potential (EC50 values 96 ± 1 to 190 ± 6 μg/mL), and also the highest concentration of cinnamic acid (656 to 156 μg/g), which was also the individual compound with the highest anti-inflammatory activity.” ABSTRACT: In the present study, …

Read More The contribution of phenolic acids to the anti-inflammatory activity of mushrooms

Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

“Our results suggest that CmNo1 possesses strong hypoglycemic, anticholesterolemic, and antihypertriglyceridemic actions and is more economical alternate for DM treatment.” ABSTRACT: Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion. Hypoglycemic medications for type 2 DM have either proven inadequate or posed …

Read More Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Lanosterol reverses protein aggregation in cataracts

“Our study identifies lanosterol as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for cataract prevention and treatment.” ABSTRACT: The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index. Any disruption of intra- or …

Read More Lanosterol reverses protein aggregation in cataracts

Potential of submergedly cultivated mycelia of Ganoderma spp. as antioxidant and antimicrobial agents

“Results obtained by both disc-diffusion and microdilution methods indicated that the extract of G. lucidum BEOFB 433 was the most potent antibacterial agent that inhibited growth of almost all bacterial species at a concentration of 1.0 mg/mL.” ABSTRACT: The study aimed to evaluate the antiradical and antimicrobial (antibacterial and antifungal) potentials of ethanol mycelial extracts …

Read More Potential of submergedly cultivated mycelia of Ganoderma spp. as antioxidant and antimicrobial agents