Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guérin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion

“…ethanol extract of Ganoderma lucidum… [suggests]…potential implications of GL to supplement the BCG immunotherapy in bladder cancer, for better efficacy and reducing side effects.”  ABSTRACT: Bacillus Calmette-Guérin (BCG) is conventionally used as an adjuvant immunotherapy to reduce the recurrence of bladder cancer. To address the issues of efficacy and safety, an ethanol extract of Ganoderma …

Read More Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guérin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion

Recent developments in mushrooms as anti-cancer therapeutics: a review

“The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.”  ABSTRACT: From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice. The last decade has witnessed the overwhelming interest of …

Read More Recent developments in mushrooms as anti-cancer therapeutics: a review

Mushroom Polysaccharide protects Radiation Induced Intestinal Damage in Mice

“The in vivo radioprotective effect of a polysaccharide (PS) isolated from the mushroom Ganoderma lucidum, against radiation (RT) induced intestinal damage was investigated…PS can be developed to an effective natural radioprotector without any side effects, after further studies.”  ABSTRACT: The in vivo radioprotective effect of a polysaccharide (PS) isolated from the mushroom Ganoderma lucidum, against …

Read More Mushroom Polysaccharide protects Radiation Induced Intestinal Damage in Mice

Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

“…PBR [Phellinus linteus grown on germinated brown rice] ameliorated the pathological characteristics of colitis such as shortening of colon length and improved the disease activity index score.”  ABSTRACT: Ethnopharmacological relevance and aim of the study: Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that …

Read More Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

Enhancement of Wheat Grain Antioxidant Activity by Solid State Fermentation with Grifola spp.

“…solid state fermentation [SSF] of wheat grains with mycelia of those Grifola spp. was used to obtain biotransformed wheat grain flour…a valuable food alternative can easily be obtained with wheat grains, that is, by markedly increasing their antioxidant value through SSF with Grifola spp..”  ABSTRACT: Grifola frondosa, Grifola gargal, and Grifola sordulenta are edible and …

Read More Enhancement of Wheat Grain Antioxidant Activity by Solid State Fermentation with Grifola spp.

HPLC Determination of Phenolics and Free Radical Scavenging Activity of Ethanolic Extracts of Two Polypore Mushrooms

“Present study aimed to demonstrate free radical scavenging (antioxidant) activity of ethanolic extracts of Ganoderma lucidum and Trametes hirsuta in in vitro conditions…TPC, HPLC studies and the free radical scavenging assays suggest that the two extracts have significant antioxidant potential and proved rich sources of antioxidants.” ABSTRACT: Objective: Present study aimed to demonstrate free radical …

Read More HPLC Determination of Phenolics and Free Radical Scavenging Activity of Ethanolic Extracts of Two Polypore Mushrooms

Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation

“This paper describes how a specific combination of fungal supplements can help improve the performance of endurance athletes…After 3 months of fungal supplementation, the data demonstrate an increased scavenger capacity of free radicals in the athletes’ serum after the race, thereby protecting the athletes from oxidative stress…Daily fungal supplementation consisted of 1335 mg of standardized …

Read More Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation

In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts

“…we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells…all of the fungi ethanol extracts used in this …

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Preliminary Phytochemical Analysis and Antibacterial Activity of Ganoderma lucidum collected from Dang District of Gujarat, India

“…an attempt has been made in this study to examine the antibacterial activity of various extracts of G. lucidum…methanolic extract of G. lucidum showed the strongest antibacterial activity…”  ABSTRACT: G. lucidum has been used for hundreds of years as a health promotion and treatment strategy. The emergence of new infections, drug resistant bacteria, high costs …

Read More Preliminary Phytochemical Analysis and Antibacterial Activity of Ganoderma lucidum collected from Dang District of Gujarat, India

Studies on the Antidiabetic Activities of Cordyceps militaris Extract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

“Diabetic rats were orally administered with water extract or alcohol extract [of Cordyceps militaris]…Cordyceps militaris extracts displayed a significant reduction in blood glucose levels by promoting glucose metabolism and strongly suppressed total cholesterol and triglycerides concentration in serum…The inhibitory effects on blood urea nitrogen, creatinine, uric acid, and protein revealed the protection of Cordyceps militaris …

Read More Studies on the Antidiabetic Activities of Cordyceps militaris Extract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

Concentration variation and molecular characteristics of soluble (1,3;1,6)-ß-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium

“Twelve mycelium samples examined in this study demonstrated the quantitative molecular characteristics of soluble (1,3:1,6)-β-d-Glucans…(1,3:1,6)-β-Glucan was proposed as a putative bioactive marker for immunomodulation because it was the most abundant polysaccharide in G. lucidum mycelium products to stimulate macrophage…cells…”  ABSTRACT: (1,3)-β-d-Glucans with (1,6)-β-d-glucosyl branches are bioactive polysaccharides in fruiting bodies and mycelia of Ganoderma lucidum, …

Read More Concentration variation and molecular characteristics of soluble (1,3;1,6)-ß-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium

Protection Against Lung Cancer Patient Plasma-Induced Lymphocyte Suppression by Ganoderma lucidum Polysaccharides

“This study was conducted to determine the potential of Ganoderma lucidum polysaccharides (Gl-PS) in production against lung cancer patient plasma-induced suppression of lymphocytes…Lung cancer patient plasma-induced suppression of lymphocyte activation of phytohemagglutinin may be antagonized fully or partially gy Gl-PS…”  ABSTRACT: Background/Aims: This study was conducted to determine the potential of Ganoderma lucidum polysaccharides (Gl-PS) …

Read More Protection Against Lung Cancer Patient Plasma-Induced Lymphocyte Suppression by Ganoderma lucidum Polysaccharides

Photo morphogenesis and Photo response of the blue-light receptor gene Cmwc-1 in different strains of Cordyceps militaris

“Light is a necessary environmental factor for stroma formation and development of Cordyceps militaris, a well-known edible and medicinal fungus…The results suggest that light was essential for colony pigmentation and could promote conidia production.”  ABSTRACT: Light is a necessary environmental factor for stroma formation and development of Cordyceps militaris, a well-known edible and medicinal fungus. …

Read More Photo morphogenesis and Photo response of the blue-light receptor gene Cmwc-1 in different strains of Cordyceps militaris

Structure and properties of a (1→3)-ß-D-glucan from ultrasound-degraded exopolysaccharides of a medicinal fungus

“A high molecular weight (MW) exopolysaccharide (EPS) fraction EPS1 was isolated from the fermentation broth of a medicinal fungus Cordyceps sinensis…and partially degraded by high-intensity ultrasound…suggesting its potential as a moisturizing agent for food and cosmeceutical application.”  ABSTRACT: A high molecular weight (MW) exopolysaccharide (EPS) fraction EPS1 was isolated from the fermentation broth of a …

Read More Structure and properties of a (1→3)-ß-D-glucan from ultrasound-degraded exopolysaccharides of a medicinal fungus

Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology

“This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor…For these 5 mushrooms, an abundance of in vitro evidence exists that elucidates the anticancer immunological mechanisms.”  ABSTRACT: This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps …

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LED lights increase bioactive substances at low energy costs in culturing fruiting bodies of Cordyceps militaris

“Cordyceps militaris is widely cultured to produce fruiting bodies for medicinal and health food use. Illumination is an important factor for the growth, quality and production costs…results demonstrated the functions of different wavelength lights on the growth and biosynthesis of bioactive substances and that using the low heat release and energy consumption LED lights to …

Read More LED lights increase bioactive substances at low energy costs in culturing fruiting bodies of Cordyceps militaris

Increased mycelial biomass production by Lentinula edodes intermittently illuminated by green light emitting diodes

“To study the effect of light on Lentinula edodes (the shiitake mushroom), mycelial cultures were exposed to blue, green, and red fluorescent lights and light-emitting diodes, as well as green laser light.”  ABSTRACT: Fungi possess a range of light receptors to regulate metabolism and differentiation. To study the effect of light on Lentinula edodes (the …

Read More Increased mycelial biomass production by Lentinula edodes intermittently illuminated by green light emitting diodes

Cordycepin Down-Regulates Multiple Drug Resistant (MDR)/HIF-1a through Regulating AMPK/mTORC1 Signaling in GMB-SD Gallbladder Cancer Cells

“…cordycepin, the bioactive compound in genus Cordyceps, induced growth inhibition and apoptosis in cultured gallbladder cancer cells…”  ABSTRACT: Gallbladder cancer is the most common malignancy of the bile duct, with low 5-year survival rate and poor prognosis. Novel effective treatments are urgently needed for the therapy of this disease. Here, we showed that cordycepin, the …

Read More Cordycepin Down-Regulates Multiple Drug Resistant (MDR)/HIF-1a through Regulating AMPK/mTORC1 Signaling in GMB-SD Gallbladder Cancer Cells

Anti-influenza Effect of Cordyceps militaris through Immunomodulation of DBA/2 Mouse Mode

“The immune-modulatory as well as anti-influenza of Cordyceps extract were investigated…Cordyceps extract had an anti-influenza effect that was associated with stable body weight and reduced mortality.” ABSTRACT: The immune-modulatory as well as anti-influenza effects of Cordyceps extract were investigated using a DBA/2 mouse model. Three different concentrations of Cordyceps extract, red ginseng extract, or drinking …

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Inhibition of human neutrophil elastase by ergosterol deriviatives from the mycelium of Phellinus linteus

“Numerous bioactive substances have been isolated from the fruiting bodies of P. linteus, such as polysaccharides, sterols, proteoglycans, cyclophellitol, furan derivatives, hispidin and hispolon, and their biological activities have been verified in vitro and in vivo.” ABSTRACT: The extracellular matrix (ECM) is the largest component of the dermal skin layer, and has a fundamental role …

Read More Inhibition of human neutrophil elastase by ergosterol deriviatives from the mycelium of Phellinus linteus

Antioxidative Activities of Wild Macro Fungi Ganoderma applanatum (Pers.) Pat.

“The present research work was under taken to evaluate antioxidant activity and quantitative determination of phytoconstituents of various solvent extracts of wild macro fungi Ganoderma applanatum…using in vitro models…the total phenolics and flavonoids were high and extracts showed good antioxidant capacity in DPPH radical scavenging assay compared to other in vitro models. The methanol extract …

Read More Antioxidative Activities of Wild Macro Fungi Ganoderma applanatum (Pers.) Pat.

Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization

“The stimulation effect of the six extracts and eight fractions [from Inonotus obliquus] on the four-cytokine production was dose-dependent. Sclerotial polysaccharides were more effective in the four-cytokine production at 150μg/ml while exopolysaccharides and endopolysacchrides showed a much better effect on IL-1β production at 30μg/ml. Purified fractions from exopolysaccharides and endopolysaccharides were more effective than the …

Read More Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

“We used ethanol to extract anti-cancer bioactive components enriched with terpenoids from Pleurotus ferulae. We tested the anti-tumour effects of ethanol extracts on the melanoma cell line B16F10, the human gastric cancer cell line BGC 823 and the immortalized human gastric epithelial mucosa cell line GES-1 in vitro and a murine melanoma model in vivo…PFEC …

Read More Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

An Antioxidant Hispidin from the Mycelial Cultures of Phellinus linteus

“…an antioxidant was isolated from the mycelial culture broth of Phellinus linteus and identified as hispidin. The hispidin content was reached its maximum level at 12 days after onset of inoculation. About 2.5 mg/mL of hispidin was produced by P. linteus in a yeast-malt medium (pH 5.8, 25°C). Hispidin inhibited 22.6 and 56.8% of the …

Read More An Antioxidant Hispidin from the Mycelial Cultures of Phellinus linteus

A Comparative Study of the Antimicrobial, Antioxidant, and Cytotoxic Activities of Methanol Extracts from Fruit Bodies and Fermented Mycelia of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes)

“This study assayed and compared the antimicrobial, antioxidant, and cytotoxic properties of the methanol extracts from fruiting bodies and fermented mycelia of C. militaris, as well as the contents of total phenol, flavonoids, and cordycepin. The results showed that the extracts from fruiting bodies possessed broad antimicrobial activities against all microorganisms tested (both bacteria and …

Read More A Comparative Study of the Antimicrobial, Antioxidant, and Cytotoxic Activities of Methanol Extracts from Fruit Bodies and Fermented Mycelia of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes)

Effects of Polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers

“Interactions between the microbial flora of the intestine and the human host play a critical role in maintaining intestinal health and in the pathophysiology of a wide variety of disorders such as antibiotic associated diarrhea, Clostridium difficile infection, and inflammatory bowel disease. Prebiotics can confer health benefits by beneficial effects on the intestinal microbiome, whereas …

Read More Effects of Polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers

Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro

“The genera of the human microbiota that are promoted by FOS and other prebiotics are also stimulated by the Trametes versicolor extract, PSP. Thus, Trametes versicolor, a common East Asian botanical, contains putative prebiotic agents that alter human gut microbiota and pH. This prebiotic-like activity may help explain some of the plethora of the health …

Read More Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro

Effect of Extraction Media on Preliminary Characterizations and Antioxidant Activities of Phellinus linteus Polysaccharides

“[Ammonium-oxalate and sodium-hydroxide/sodium-borohydride extracts of Phellinus linteus mycelium] had better antioxidant activities [than hot water extracts] and could thus be developed as potential natural antioxidant agents for applications in food additives and biomedical industries.” ABSTRACT: Three partially purified polysaccharides were extracted from Phellinus linteus mycelia using hot water, 1% (NH4)2C2O4, and 1.25M NaOH/0.05% NaBH4, and …

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A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

“The majority of Ganoderma triterpenes exhibit a wide range of biological activities, including antitumor, anti-HIV-1, antihypertensive, antiangiogenic, immunomodulatory, antiandrogenic, antihepatitis B, antioxidant, anticomplement, and antimicrobial activities [10–13].” ABSTRACT: Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, popularly used for complementary cancer therapy. GTs are lanostane-tetracyclic triterpenes. They have …

Read More A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

“Bioactive polysaccharides have been isolated from the fruiting bodies of G. lucidum and from the mycelia cultivated in liquid culture. Some polysaccharides have also been isolated from the culture medium of growing mycelium (extracellular polysaccharides).” ABSTRACT: Ganoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been …

Read More Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities