Modulation of T cell response by Phellinus linteus

“P. linteus fermented broths produced additive effects on the regulation of the Th1/Th2 balance and show promise for the development of immunomodulatory therapeutics.” ABSTRACT: Phellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective …

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Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

“Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels-but also maintains intestinal barrier integrity and reduces metabolic endotoxemia. The anti-obesity and microbiota-modulating effects are transmissible via horizontal faeces transfer from WEGL-treated mice to HFD-fed mice.” ABSTRACT: Obesity is associated with low-grade chronic inflammation …

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Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties

“These results indicate that different extracts of investigated mushroom have considerable cytotoxic, antioxidant and antibacterial properties and may be utilized as a promising source of therapeutics.” ABSTRACT: BACKGROUND: Mushrooms have been valued for their nutritive content and as traditional medicines; several important medicinal properties of mushrooms have been recognized worldwide. OBJECTIVE: The purpose of this …

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Regulation of primary metabolic pathways in oyster mushroom mycelia induced by blue light stimulation: Accumulation of shikimic acid

“Shikimic acid is a key intermediate in the aromatic amino acid pathway as well as an important starting material for the synthesis of Tamiflu, a potent and selective inhibitor of the neuraminidase enzyme of influenza viruses A and B. Here we report that in oyster mushroom (Pleurotus ostreatus) mycelia cultivated in the dark, stimulation with …

Read More Regulation of primary metabolic pathways in oyster mushroom mycelia induced by blue light stimulation: Accumulation of shikimic acid

Evaluation of the Antioxidant Activities and Tyrosinase Inhibitory Property from Mycelium Culture Extracts

“Overall, our study suggested potential candidates for [ethanol extract of culture media including mycelium] that exhibited powerful antioxidant and tyrosinase inhibitory properties and might be used as natural antioxidant tyrosinase inhibitor.” ABSTRACT: Since mushrooms have many bioactive components, they have been used as components in folk medicine. Because mycelium has an advantage when it comes …

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Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

“Atractylenolide I has not been reported in mushrooms or rice as of yet. The isolated compound dose-dependently inhibited the growth of HT-29 human colon cancer cells.” ABSTRACT: Objective: To isolate and identify the anticancer compound against proliferation cancer cells from ethyl acetate (EtOAc) extract of Phellinus linteus grown on germinated brown rice (PB). Methods: EtOAc …

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Chemical, toxicological, anti-inflammatory and antimicrobial evaluation of Ganoderma lucidum extracts

“When a mixture is made of water extract with alcohol, there is a higher concentration of beta-glucan with protein and phenol.” ABSTRACT: Ganoderma lucidum (Fr.) Krast, a basidiomycete belonging to the Ganodermataceae family is one of the most famous traditional Chinese medicinal herbs, used as a healthy food and in medicine. In Brazil, some people …

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The contribution of phenolic acids to the anti-inflammatory activity of mushrooms

“The extracts of Pleurotus ostreatus, Macrolepiota procera, Boletus impolitus and Agaricus bisporus revealed the strongest anti-inflammatory potential (EC50 values 96 ± 1 to 190 ± 6 μg/mL), and also the highest concentration of cinnamic acid (656 to 156 μg/g), which was also the individual compound with the highest anti-inflammatory activity.” ABSTRACT: In the present study, …

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Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

“Our results suggest that CmNo1 possesses strong hypoglycemic, anticholesterolemic, and antihypertriglyceridemic actions and is more economical alternate for DM treatment.” ABSTRACT: Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion. Hypoglycemic medications for type 2 DM have either proven inadequate or posed …

Read More Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Lanosterol reverses protein aggregation in cataracts

“Our study identifies lanosterol as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for cataract prevention and treatment.” ABSTRACT: The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index. Any disruption of intra- or …

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Potential of submergedly cultivated mycelia of Ganoderma spp. as antioxidant and antimicrobial agents

“Results obtained by both disc-diffusion and microdilution methods indicated that the extract of G. lucidum BEOFB 433 was the most potent antibacterial agent that inhibited growth of almost all bacterial species at a concentration of 1.0 mg/mL.” ABSTRACT: The study aimed to evaluate the antiradical and antimicrobial (antibacterial and antifungal) potentials of ethanol mycelial extracts …

Read More Potential of submergedly cultivated mycelia of Ganoderma spp. as antioxidant and antimicrobial agents