Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards the 5-HT2AR, the 5-HT2BR and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT2AR and 5-HT2BR and one compound showed a higher selectivity towards 5-HT2AR than psilocin.
Vandevelde, M., Simoens, A., Vandekerckhove, B., & Stevens, C. V. (2024). Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond. RSC Medicinal Chemistry. https://doi.org/10.1039/D4MD00043A