Lion’s mane (Hericium erinaceus) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sautéing, barbecuing, stir-frying, or baking. Lion’s mane taste and texture is often compared to crab or other seafood, which makes it a highly sought-after edible mushroom species. Lion’s mane has a long history of medicinal use in Asian cultures, dating back millennia. Recent research indicates potential health benefits include avoiding dementia and improving cognitive function; easing depression and anxiety; reducing risk of heart disease; diminishing diabetes symptoms and improved immune system function. Evidence of improved cognitive function has been particularly significant and well documented. Certain individuals should avoid consuming lion’s mane mushrooms or supplements due to potential health risks. This includes individuals with bleeding disorders or taking blood thinners and people with diabetes taking blood sugar-lowering medications. While published peer reviewed scientific studies of lion’s mane mushrooms effects continues to grow, much of the current evidence is based on non-human animal and laboratory studies. More human research is needed to determine the full extent of its health benefits for a growing interested public. Nonetheless, the identification of specific lion’s mane bioactive compounds, hericenones and erinacines, has sparked significant interest in both research and medical communities, paving the way for future applications in brain, heart, blood, and overall health.